MHC class I antigens, immune surveillance, and tumor immune escape
نویسندگان
چکیده
منابع مشابه
Tumor escape from immune surveillance.
The bases for an efficient anti-tumor immune response begin to be better defined. Nonetheless, neoplastic cells develop various strategies to escape immune surveillance, which are discussed here in order to better design the therapeutic possibilities of immune manipulation. The absence of specific tumor antigen as well as the weak expression of major histocompatibility complex (MHC) molecules h...
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Los tumores deben evadir la respuesta inmunológica para ser clínicamente detectables en el paciente. A estos fines, las células cancerosas han desarrollado múltiples estrategias para eludir el ataque inmunológico. Estos mecanismos conspiran en estadíos avanzados de un tumor limitando la habilidad del sistema inmune para inhibir el crecimiento tumoral y la efectividad de estrategias de inmunoter...
متن کاملTumor Rejection Antigens and Immune Surveillance
The existence of specific tumor rejection antigens was first demonstrated with chemically induced mouse sarcomas: each tumor was found to express a different antigen [1]. Similar findings were made with ultraviolet-induced tumors [2]. Later, the generality of the existence of tumor rejection antigens was questioned when spontaneous mouse tumors were found to be completely incapable of eliciting...
متن کاملParadoxical effects of cytokines in tumor immune surveillance and tumor immune escape.
The role of cytokines in modulating the formation of new tumors is mediated by their ability to regulate antigen-specific anti-tumor responses and by the activation of non-specific mechanisms, including those involved in the processes of inflammation and innate resistance. Cytokines may influence the growth of tumors by acting directly on tumor cells as growth promoting or growth inhibiting fac...
متن کاملThe Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture
Tumor immune escape is associated with the loss of tumor HLA class I (HLA-I) expression commonly found in malignant cells. Accumulating evidence suggests that the efficacy of immunotherapy depends on the expression levels of HLA class I molecules on tumors cells. It also depends on the molecular mechanism underlying the loss of HLA expression, which could be reversible/"soft" or irreversible/"h...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2003
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.10290